Water → 1,2-Dihydro-6-methyl-5-(imidazo[1,2-a]pyridin-6-yl)-2-oxo-pyridine

HRID 414315

반응식

HRID 414315 반응식
[CH3:1][C:2]1[NH:7][C:6](=[O:8])[C:5](C#N)=[CH:4][C:3]=1[C:11]1[CH:12]=[CH:13][C:14]2[N:15]([CH:17]=[CH:18][N:19]=2)[CH:16]=1.O.O.N>P(=O)(O)(O)O>[CH3:1][C:2]1[NH:7][C:6](=[O:8])[CH:5]=[CH:4][C:3]=1[C:11]1[CH:12]=[CH:13][C:14]2[N:15]([CH:17]=[CH:18][N:19]=2)[CH:16]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 4593OlprinoneHCID 12896473Azane;hydrate

생성물 1

HCID 138523301,2-Dihydro-6-methyl-5-(imidazo[1,2-a]pyridin-6-yl)-2-oxo-pyridine수율 44.4%

시약·촉매·용매 1

HCID 1004Phosphoric Acid용매

실험 절차

In 10 ml of 85% phosphoric acid was refluxed 1 g of 1,2-dihydro-6-methyl-5-(imidazo[1,2-a]pyridin-6-yl)-2-oxo-3-pyridinecarbonitrile for 18 hours. After cooling, water was added and then conc. ammonia water was further added to the reaction mixture to render the mixture alkaline. The mixture was extracted with chloroform. After washing with water and drying over magnesium sulfate, chloroform was removed by distillation under reduced pressure. The residue was recrystallized from ethanol-ether to obtain 0.4 g of 1,2-dihydro-6-methyl-5-(imidazo[1,2-a]pyridin-6-yl)-2-oxo-pyridine.

후처리

  1. temperatureAfter cooling
  2. extractionThe mixture was extracted with chloroform
  3. washAfter washing with water
  4. dry with materialdrying over magnesium sulfate, chloroform
  5. customwas removed by distillation under reduced pressure
  6. customThe residue was recrystallized from ethanol-ether

출처 및 근거

ORD 기록
ord-deaf50ac95c54fa5b029f10b0eaf4181
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04791202

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