Isopropyl isocyanate → 1-N-i-Propylcarbamoyloxindole

HRID 414419

반응식

HRID 414419 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[CH:11]([N:14]=[C:15]=[O:16])([CH3:13])[CH3:12]>C1(C)C=CC=CC=1>[CH:11]([NH:14][C:15]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10])=[O:16])([CH3:13])[CH3:12]

참가 물질

4

반응물 2

HCID 61277Isopropyl isocyanateHCID 321710Oxindole

생성물 1

HCID 135656731-N-i-Propylcarbamoyloxindole

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a stirred suspension of 5.0 g. (37.6 mmole) of 2-oxindole in 50 ml. of toluene was added 8.0 g. (94.0 mmole) of isopropyl isocyanate, and the mixture was heated under reflux for 6 hours. The reaction mixture was allowed to cool and then it was stirred at room temperature overnight. The solvent was removed by evaporation in vacuo, and the residue was dissolved in hot cyclohexane. The solution was allowed to cool and the solid was collected by filtration, giving 7.0 g. of the title compound, m.p. 84°-85.5° C., as pink crystals.

후처리

  1. additionTo a stirred suspension of 5.0 g
  2. temperatureunder reflux for 6 hours
  3. temperatureto cool
  4. customThe solvent was removed by evaporation in vacuo
  5. dissolutionthe residue was dissolved in hot cyclohexane
  6. temperatureto cool
  7. filtrationthe solid was collected by filtration
  8. customgiving 7.0 g

출처 및 근거

ORD 기록
ord-b2ae65b02c1a44a68d12fab049b98aab
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04791129

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