Nicotinic Acid → Norfloxacin nicotinate

HRID 414447

반응식

HRID 414447 반응식
[CH3:1][CH2:2][N:3]1[C:9]2[CH:10]=[C:11]([N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)[C:12]([F:14])=[CH:13][C:8]=2[C:6](=[O:7])[C:5]([C:21]([OH:23])=[O:22])=[CH:4]1.C(O)(=O)C1C=CC=NC=1>C(O)C>[C:21]([OH:23])(=[O:22])[C:5]1[CH:6]=[CH:8][CH:9]=[N:3][CH:4]=1.[CH3:1][CH2:2][N:3]1[C:9]2[CH:10]=[C:11]([N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)[C:12]([F:14])=[CH:13][C:8]=2[C:6](=[O:7])[C:5]([C:21]([OH:23])=[O:22])=[CH:4]1

참가 물질

4

반응물 2

HCID 938Nicotinic AcidHCID 4539Norfloxacin

생성물 1

HCID 83908Norfloxacin nicotinate수율 88%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

10 g of Norfloxacin were added to 20 ml of ethanol, the mixture obtained was then stirred and heated to reflux. 4.2 g of nicotinic acid, previously dissolved in 5 ml of hot ethanol, were added in one portion to said mixture and the resulting suspension was heated to reflux, upon which all solids dissolved. After a short time at reflux the adduct began to separate. The mixture was stirred, cooled to room temperature and finally in an ice bath to yield the nicotinic acid-Norfloxacin 1:1 adduct in 88% yield; m.p. 232°-233° C.

후처리

  1. customthe mixture obtained
  2. temperatureheated to reflux
  3. additionwere added in one portion
  4. temperaturethe resulting suspension was heated
  5. temperatureto reflux, upon which all solids
  6. dissolutiondissolved
  7. temperatureAfter a short time at reflux the adduct
  8. customto separate
  9. stirringThe mixture was stirred

출처 및 근거

ORD 기록
ord-d1c114c294724bda82cd49333e3ac512
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04792552

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