Sodium borohydride → 6-[1-Hydroxy-2-(imidazol-1-yl)ethyl]-3,4-dihydrocarbostyril
반응식
[N:1]1([CH2:6][C:7]([C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[NH:15][C:14](=[O:19])[CH2:13][CH2:12]3)=[O:8])[CH:5]=[CH:4][N:3]=[CH:2]1.[BH4-].[Na+]>CO>[OH:8][CH:7]([C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[NH:15][C:14](=[O:19])[CH2:13][CH2:12]2)[CH2:6][N:1]1[CH:5]=[CH:4][N:3]=[CH:2]1참가 물질
4
실험 절차
A solution of 3.0 g of 6-(imidazol-1-ylacetyl)-3,4-dihydrocarbostyril (the preparation of which is given in Example 3) in 120 ml of methanol was reacted with 1.2 g of sodium borohydride in the same manner as shown in Preparation 2, and the product similarly isolated to give 6-[1-hydroxy-2-(imidazol-1-yl)ethyl]-3,4-dihydrocarbostyril, m.p. 182°-184°
후처리
- customas shown in Preparation 2
- customthe product similarly isolated
출처 및 근거
- ORD 기록
- ord-2e13988fc0894e948f18828a378db452
- 출처 데이터셋
- uspto-grants-1988_12
- 특허 번호
- US04792561
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