3-Chloro-2-methyl-1-propene → 4-Methyl-7-methallyloxy-1-indanone

HRID 414683

반응식

HRID 414683 반응식
[CH3:1][C:2]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:12].[OH-].[K+].[CH2:15](Cl)[C:16](=[CH2:18])[CH3:17]>CO>[CH3:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][CH2:17][C:16](=[CH2:15])[CH3:18])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:12]

참가 물질

5

반응물 3

HCID 112413-Chloro-2-methyl-1-propeneHCID 14797Potassium HydroxideHCID 124362447-Hydroxy-4-methyl-1-indanone

생성물 1

HCID 136041514-Methyl-7-methallyloxy-1-indanone

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Into a solution of 15 g of 4-methyl-7-hydroxy-1-indanone and 7.95 g of potassium hydroxide in 200 ml of methanol was added 13.55 ml of methallyl chloride, and the mixture was refluxed by heating for 11 hours. The insoluble matters in the reaction mixture were removed by filtration, then the solvent was removed by evaporation. The residue obtained was purified by means of a silica gel column chromatography (eluent: n-hexane: dichloromethane=1:1) to obtain 9 g of 4-methyl-7-methallyloxy-1-indanone.

후처리

  1. temperaturethe mixture was refluxed
  2. temperatureby heating for 11 hours
  3. customThe insoluble matters in the reaction mixture were removed by filtration
  4. customthe solvent was removed by evaporation
  5. customThe residue obtained
  6. customwas purified by means of a silica gel column chromatography (eluent: n-hexane: dichloromethane=1:1)

출처 및 근거

ORD 기록
ord-cd8b7b060be64f7289e4470cda2668f0
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04792628

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