Hydrochloric Acid → 1-Amino-7-hydroxy-4-methylindane hydrochloride

HRID 414687노트

반응식

HRID 414687 반응식
[OH:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:13])=[C:6]2[C:10]=1[C:9](=[N:11]O)[CH2:8][CH2:7]2.[H][H].[ClH:16]>C(O)(=O)C.[Pt]=O.C(O)C>[ClH:16].[NH2:11][CH:9]1[C:10]2[C:6](=[C:5]([CH3:13])[CH:4]=[CH:3][C:2]=2[OH:1])[CH2:7][CH2:8]1

참가 물질

7

반응물 3

HCID 313Hydrochloric AcidHCID 1363428377-Hydroxy-4-methyl-1-indanone oximeHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 136041701-Amino-7-hydroxy-4-methylindane hydrochloride

시약·촉매·용매 3

HCID 82844Platinum oxide (PtO)촉매HCID 176Acetic Acid용매HCID 702Ethanol용매

실험 절차

15.0 Grams of 7-hydroxy-4-methyl-1-indanone oxime was dissolved in 200 ml of acetic acid, then 1.0 g of platinum oxide catalyst was added thereto and the mixture was subjected to catalytic reduction under 5 atmospheric pressure of hydrogen gas at a room temperature for 8 hours. The catalyst was removed by filtration, then the filtrate was concentrated to dryness under a reduced pressure. The residue thus obtained was dissolved in 200 ml of ethanol and hydrogen chloride gas was blown into the solution to become saturated. The solvent was removed by evaporation under a reduced pressure, the residue was recrystallized from ethanol to obtain 3.30 g of 1-amino-7-hydroxy-4-methylindane hydrochloride in the form of colorless needle-like crystals. Melting point: 221°-223° C.

후처리

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated to dryness under a reduced pressure
  3. customThe residue thus obtained
  4. customThe solvent was removed by evaporation under a reduced pressure
  5. customthe residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-f6655bee8571400c83811f3302bde56e
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04792628

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