Sodium Hydroxide → 5-(1H-Tetrazol-1-yl)pentanoic acid

HRID 414738노트

반응식

HRID 414738 반응식
C([O:3][C:4](=[O:14])[CH2:5][CH2:6][CH2:7][CH2:8][N:9]1[CH:13]=[N:12][N:11]=[N:10]1)C.[OH-].[Na+]>CO>[N:9]1([CH2:8][CH2:7][CH2:6][CH2:5][C:4]([OH:14])=[O:3])[CH:13]=[N:12][N:11]=[N:10]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 53833799(5-Tetrazol-1-yl)-valeric acid ethyl ester

생성물 1

HCID 212802905-(1H-Tetrazol-1-yl)pentanoic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2.12 g of (5-tetrazol-1-yl)-valeric acid ethyl ester are dissolved in 5 ml of methanol, and 4.28 ml of a methanolic NaOH solution (3N) are added. After stirring for 2.5 hours at room temperature, the solvent is distilled off and the residue is taken up in water. After washing with ethyl acetate, the aqueous phase is acidified (pH 3) and extracted twice with ethyl acetate. After drying and concentration by evaporation, the pure title compound is obtained.

후처리

  1. distillationthe solvent is distilled off
  2. washAfter washing with ethyl acetate
  3. extractionextracted twice with ethyl acetate
  4. customAfter drying
  5. concentrationconcentration
  6. customby evaporation

출처 및 근거

ORD 기록
ord-414e0b081d944a87a3826097904e4a0d
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04794109

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