Pyridine → N-Methoxy-N-methyl-1H-indazole-3-carboxamide

HRID 414924

반응식

HRID 414924 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]([OH:12])=O)=[N:2]1.Cl.[CH3:14][NH:15][O:16][CH3:17].CN(C)CCCN=C=NCC.N1C=CC=CC=1>O1CCCC1>[CH3:17][O:16][N:15]([CH3:14])[C:10]([C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[NH:1][N:2]=1)=[O:12]

참가 물질

6

반응물 4

HCID 1049PyridineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 78250Indazole-3-carboxylic acidHCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)

생성물 1

HCID 16036867N-Methoxy-N-methyl-1H-indazole-3-carboxamide수율 69.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

In a round-bottomed flask, 4.0 g of 1H-indazole-3-carboxylic acid, 2.6 g of N,O-dimethylhydroxylamine hydrochloride, 9.4 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and 8.4 ml of pyridine are placed in 120 ml of tetrahydrofuran. The mixture is stirred at ambient temperature for 20 h. The mixture is concentrated and the residue is taken up in water. The yellow precipitate obtained is washed with water and then dried under reduced pressure. 3.5 g of compound are obtained.

후처리

  1. concentrationThe mixture is concentrated
  2. customThe yellow precipitate obtained
  3. washis washed with water
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-9738909b5b2b4a118505adb3bac6ad7f
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088765B2

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