Propylamine → 2-(3-Chlorobenzyl)-6-oxo-4-(propylamino)-1,6-dihydropyrimidine-5-carbonitrile

HRID 414963노트

반응식

HRID 414963 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[CH2:5][C:6]1[NH:7][C:8](=[O:16])[C:9]([C:14]#[N:15])=[C:10](SC)[N:11]=1.[CH2:20]([NH2:23])[CH2:21][CH3:22]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[CH2:5][C:6]1[NH:7][C:8](=[O:16])[C:9]([C:14]#[N:15])=[C:10]([NH:23][CH2:20][CH2:21][CH3:22])[N:11]=1

참가 물질

3

반응물 2

HCID 7852PropylamineHCID 584078022-(3-Chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

생성물 1

HCID 1359950062-(3-Chlorobenzyl)-6-oxo-4-(propylamino)-1,6-dihydropyrimidine-5-carbonitrile

실험 절차

In analogy to the preparation of Example 1, 100 mg (0.34 mmol) of 2-(3-chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are reacted with 203 mg (3.43 mmol) of n-propylamine to give 12 mg (12% of theory) of the title compound.

출처 및 근거

ORD 기록
ord-d506f5c8116c4d91a53dc00e96965c69
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088769B2

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