Hydrochloric Acid → (RS)-2-bromo-6-(1-hydroxyheptyl)anisole

HRID 41526

반응식

HRID 41526 반응식
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[C:3]=1[O:9][CH3:10].[CH:11](=[O:18])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].Cl>C1COCC1>[Br:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH:11]([OH:18])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[C:3]=1[O:9][CH3:10]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 8130HeptanalHCID 181584Benzene, 1,3-dibromo-2-methoxy-

생성물 1

HCID 59544889(RS)-2-bromo-6-(1-hydroxyheptyl)anisole수율 79%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
40 °C

실험 절차

To a THF solution of 2,6-dibromoanisole (10 g, 37.6 mmol) was added Mg (0.90 g, 37.6 mmol), and the mixture was heated and stirred at 40° C. Under ice-cooling, n-heptanal (47.2 g, 41.3 mmol) was added dropwise. Aqueous hydrochloric acid solution was added to the reaction mixture, this was extracted with ethyl acetate, and the solvent was distilled off to obtain 8.95 g of a compound (1).

후처리

  1. temperaturethe mixture was heated
  2. temperatureUnder ice-cooling
  3. extractionthis was extracted with ethyl acetate
  4. distillationthe solvent was distilled off

출처 및 근거

ORD 기록
ord-0586628f68394c568875f29b5148eba6
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530668B2

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