p-Toluenesulfonic acid → Methyl Caffeate

HRID 416031

반응식

HRID 416031 반응식
[C:1]([OH:13])(=[O:12])/[CH:2]=[CH:3]/[C:4]1[CH:11]=[CH:10][C:8]([OH:9])=[C:6]([OH:7])[CH:5]=1.[CH3:14]C1C=CC(S(O)(=O)=O)=CC=1.COC(OC)(C)C>CO>[C:1]([O:13][CH3:14])(=[O:12])/[CH:2]=[CH:3]/[C:4]1[CH:11]=[CH:10][C:8]([OH:9])=[C:6]([OH:7])[CH:5]=1

참가 물질

5

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 64952,2-DimethoxypropaneHCID 689043Caffeic Acid

생성물 1

HCID 689075Methyl Caffeate수율 98%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Put a 10 g caffeic acid (1) in a reaction bottle, and add 1 g TsOH and 3 ml 2,2-dimethoxypropane and 10 ml methanol thereinto, followed by refluxing for 6 hours. After the refluxation, remove the solvent and pour the resultant solution into 100 ml water, followed by being extracted by the ethyl acetate for three times, neutralizing with 3% NaHCO3, and finally performing a column chromatography. Therefore, the product, methyl caffeate (the compound 2) is obtained with 98% yield.

후처리

  1. temperatureby refluxing for 6 hours
  2. customAfter the refluxation, remove the solvent
  3. additionpour the resultant solution into 100 ml water
  4. extractionby being extracted by the ethyl acetate for three times

출처 및 근거

ORD 기록
ord-8061bc708c5948a997c7e01eb3eddcbe
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088818B2

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