2-Nitrobenzoyl chloride → HCID 59680188, 화합물

HRID 416637

반응식

HRID 416637 반응식
[OH:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[NH2:8].[N+:9]([C:12]1[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=1[C:14](Cl)=[O:15])([O-:11])=[O:10].OC1C=CN=CC=1[C:28]1[C:29]([N+:37]([O-:39])=[O:38])=[C:30]([CH:34]=[CH:35][CH:36]=1)[C:31]([NH2:33])=O.P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:41]>N1C=CC=CC=1.CC1C=CC(C)=CC=1>[OH:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[NH:8][C:14](=[O:15])[C:13]1[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=1[N+:9]([O-:11])=[O:10].[N+:37]([C:29]1[CH:28]=[CH:36][CH:35]=[CH:34][C:30]=1[C:31]1[S:41][C:2]2[CH:7]=[CH:6][N:5]=[CH:4][C:3]=2[N:33]=1)([O-:39])=[O:38]

참가 물질

8

반응물 4

HCID 118752-Nitrobenzoyl chlorideHCID 14817Phosphorus sulfide (P2S5)HCID 2333923-Amino-4-hydroxypyridineHCID 178513633HCID 178513633, 화합물

생성물 2

HCID 59680188HCID 59680188, 화합물수율 55%HCID 178522382HCID 178522382, 화합물

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 7809P-Xylene용매

반응 조건

온도
140 °C

실험 절차

N-(4-Hydroxy-pyridin-3-yl)-2-nitro-benzamide was prepared using a procedure similar to that described above using 4-hydroxy-3-aminopyridine and 2-nitrobenzoyl chloride. A mixture of -(4-Hydroxy-pyridin-3-yl)-2-nitro-benzamide (2.6 g, 0.01 mol) and P2S5 (4.44 g, 0.02 mol) in pyridine (12.5 mL) and p-xylene (50 mL) was stirred at 140° C. for 18 hrs. The solvent was removed under vacuo and the residue was purified by recrystallization to give 2-(2-nitrophenyl)thiazolo[4,5-c]pyridine as a yellow solid (1.43 g, yield: 55%).

후처리

  1. customThe solvent was removed under vacuo
  2. customthe residue was purified by recrystallization

출처 및 근거

ORD 기록
ord-dde622f69e674e3abd2aa110c60d2869
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088928B2

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