Sodium borohydride → 1-[2-(4-Chlorophenyl)thiazol-5-yl]ethanol
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([C:13](=[O:15])[CH3:14])=[CH:11][N:12]=2)=[CH:4][CH:3]=1.[BH4-].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:9][C:10]([CH:13]([OH:15])[CH3:14])=[CH:11][N:12]=2)=[CH:6][CH:7]=1참가 물질
4
실험 절차
To a suspension of 1-[2-(4-chloro-phenyl)-thiazol-5-yl]ethanone (5 g, 21 mmol) in methanol (100 ml) is added sodium borohydride (832 mg, 22 mmol) at room temperature. The reaction mixture is stirred at room temperature for 0.5 hour. The reaction mixture is quenched with 100 ml of an aqueous saturated solution of ammonium chloride, extracted with dichloromethane (2×150 ml). The combined organic extracts are dried over magnesium sulphate, filtered and evaporated to dryness to give 1-[2-(4-chloro-phenyl)-thiazol-5-yl]ethanol (4.88 g).
후처리
- customThe reaction mixture is quenched with 100 ml of an aqueous saturated solution of ammonium chloride
- extractionextracted with dichloromethane (2×150 ml)
- dry with materialThe combined organic extracts are dried over magnesium sulphate
- filtrationfiltered
- customevaporated to dryness
출처 및 근거
- ORD 기록
- ord-9c642914da4d4470aa47031ae72f88b8
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08530667B2
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