4-[3-[6-(3-Acetyl-5-thiophen-3-yl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester → 4-[3-[6-(3-Acetyl-5-thiophen-3-yl-phenoxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy]-butyric acid
반응식
C([O:3][C:4](=[O:43])[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]2[CH:27]=[C:26]([C:28]3[CH:32]=[CH:31][S:30][CH:29]=3)[CH:25]=[C:24]([C:33](=[O:35])[CH3:34])[CH:23]=2)[C:10]=1[CH2:36][CH2:37][C:38]([O:40]CC)=[O:39])C>[OH-].[Na+]>[C:33]([C:24]1[CH:23]=[C:22]([CH:27]=[C:26]([C:28]2[CH:32]=[CH:31][S:30][CH:29]=2)[CH:25]=1)[O:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][C:11]1[C:10]([CH2:36][CH2:37][C:38]([OH:40])=[O:39])=[C:9]([CH:14]=[CH:13][CH:12]=1)[O:8][CH2:7][CH2:6][CH2:5][C:4]([OH:43])=[O:3])(=[O:35])[CH3:34]참가 물질
3
실험 절차
A similar procedure as described in Example 43, step 5 was used, starting from 4-[3-[6-(3-acetyl-5-thiophen-3-yl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (272 mg, 0.44 mmol) and 1.0 N aqueous sodium hydroxide (10 mL) to afford 4-[3-[6-(3-acetyl-5-thiophen-3-yl-phenoxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy]-butyric acid (163 mg, 66%) as a light brown solid: ES(+)-HRMS m/e calcd for C31H36O7S (M+Na)+ 575.2074. found 575.2074.