Lithium hydroxide, monohydrate → (E)-3-(3'-Adamantan-1-yl-4'-cyanomethoxybiphenyl-4-yl)-acrylic acid

HRID 41728노트

반응식

HRID 41728 반응식
C[O:2][C:3](=[O:32])/[CH:4]=[CH:5]/[C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][C:20]#[N:21])=[C:14]([C:22]34[CH2:31][CH:26]5[CH2:27][CH:28]([CH2:30][CH:24]([CH2:25]5)[CH2:23]3)[CH2:29]4)[CH:13]=2)=[CH:8][CH:7]=1.O[Li].O>C1COCC1.O>[C:22]12([C:14]3[CH:13]=[C:12]([C:9]4[CH:8]=[CH:7][C:6](/[CH:5]=[CH:4]/[C:3]([OH:32])=[O:2])=[CH:11][CH:10]=4)[CH:17]=[CH:16][C:15]=3[O:18][CH2:19][C:20]#[N:21])[CH2:23][CH:24]3[CH2:25][CH:26]([CH2:27][CH:28]([CH2:30]3)[CH2:29]1)[CH2:31]2

참가 물질

4

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 67399554(E)-3-(3'-adamantan-1-yl-4'-cyanomethoxybiphenyl-4-yl)-acrylic acid methyl ester

생성물 1

HCID 46830625(E)-3-(3'-Adamantan-1-yl-4'-cyanomethoxybiphenyl-4-yl)-acrylic acid

시약·촉매·용매 1

HCID 21881883Oxolane--water (1/1)용매

실험 절차

(E)-3-(3′-Adamantan-1-yl-4′-cyanomethoxybiphenyl-4-yl)-acrylic acid methyl ester (240 mg, 0.56 mmol) was added to a solution of LiOH.H2O (117 mg, 2.8 mmol) in 24 ml of THF:H2O 1:1. The solution thus obtained was kept under stirring at RT overnight. THF was removed under reduced pressure and the resulting aqueous layer acidified with 1N HCl to allow the formation of the title compound as a white precipitate that was filtered (216 mg, 93%).

후처리

  1. customThe solution thus obtained
  2. customTHF was removed under reduced pressure
  3. filtrationwas filtered (216 mg, 93%)

출처 및 근거

ORD 기록
ord-bb5cc6a1eb00479a8f1f3673fb64a002
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530517B2

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