Tert-butyl malonate → HCID 178516617, 화합물

HRID 41757

반응식

HRID 41757 반응식
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[F:11][C:12]1([F:26])[CH2:17][CH2:16][CH:15]([C:18]2[CH:25]=[CH:24][C:21]([CH:22]=O)=[CH:20][CH:19]=2)[CH2:14][CH2:13]1.[C:27](OC(C)(C)C)(=[O:32])[CH2:28][C:29]([O-])=[O:30].C(=O)(OC)OC(C)(C)C[N+]#[C-].CC(C)([O-])C.[Na+]>>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:22]([C:21]4[CH:24]=[CH:25][C:18]([CH:15]5[CH2:16][CH2:17][C:12]([F:26])([F:11])[CH2:13][CH2:14]5)=[CH:19][CH:20]=4)[C:29](=[O:30])[CH2:28][C:27]3=[O:32])=[CH:9][C:4]=2[N:3]=[CH:2]1

참가 물질

6

반응물 5

HCID 21883978Tert-butyl malonateHCID 23676156Sodium t-butoxideHCID 252674641-Isocyano-2-methylpropan-2-yl methyl carbonateHCID 574884884-(4,4-Difluorocyclohexyl)benzaldehydeHCID 178507353HCID 178507353, 화합물

생성물 1

HCID 178516617HCID 178516617, 화합물

실험 절차

The compound was synthesized starting from 1H-benzo[d]imidazol-5-amine (0.71 g, 5.35 mmol), 4-(4,4-difluorocyclohexyl)benzaldehyde (1.2 g, 5.35 mmol), mono-tert-butyl malonate (0.850 mg, 5.35 mmol), 1-isocyano-2-methylpropan-2-yl methyl carbonate (0.84 g, 5.35 mmol) and sodium tert.-butoxide (0.615 g, 5.5 mmol) according to method 5.

후처리

  1. customThe compound was synthesized

출처 및 근거

ORD 기록
ord-d5bd49c8629944f98017c1268e0c9400
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530670B2

연결된 노트

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