4-(4-Methylpiperazin-1-yl)benzaldehyde → HCID 178480647, 화합물

HRID 41762

반응식

HRID 41762 반응식
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[CH3:11][N:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:25]=[CH:24][C:21]([CH:22]=O)=[CH:20][CH:19]=2)[CH2:14][CH2:13]1.[C:26](OC(C)(C)C)(=[O:31])[CH2:27][C:28]([O-])=[O:29].C(=O)(OC)OC(C)(C)C[N+]#[C-].CC(C)([O-])C.[Na+]>CO.C(Cl)Cl>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:22]([C:21]4[CH:24]=[CH:25][C:18]([N:15]5[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH2:14]5)=[CH:19][CH:20]=4)[C:28](=[O:29])[CH2:27][C:26]3=[O:31])=[CH:9][C:4]=2[N:3]=[CH:2]1

참가 물질

7

반응물 5

HCID 7365334-(4-Methylpiperazin-1-yl)benzaldehydeHCID 21883978Tert-butyl malonateHCID 23676156Sodium t-butoxideHCID 252674641-Isocyano-2-methylpropan-2-yl methyl carbonateHCID 178507353HCID 178507353, 화합물

생성물 1

HCID 178480647HCID 178480647, 화합물

시약·촉매·용매 1

HCID 21226129Dichloromethane methanol용매

실험 절차

The compound was synthesized starting from 1H-benzo[d]imidazol-5-amine (0.85 mg, 6.37 mmol), 4-(4-methylpiperazin-1-yl)benzaldehyde (1.3 g, 6.37 mmol), mono-tert-butyl malonate (1.53 g, 9.55 mmol), 1-isocyano-2-methylpropan-2-yl methyl carbonate (1.1 g, 7.01 mmol) in MeOH/CH2Cl2 1:1 (30 ml) with stirring for 2.5 days and sodium tert.-butoxide (0.235 g, 2.10 mmol) according to method 5.

후처리

  1. customThe compound was synthesized

출처 및 근거

ORD 기록
ord-6cfc93dfe97b44509fdf6828efbfefa2
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530670B2

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