Di-tert-butyl dicarbonate → tert-butyl N-(pent-4-yn-1-yl)carbamate

HRID 417850

반응식

HRID 417850 반응식
[CH2:1]([NH2:6])[CH2:2][CH2:3][C:4]#[CH:5].[O:7](C(OC(C)(C)C)=O)[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=O>C(Cl)Cl>[C:11]([O:10][C:8](=[O:7])[NH:6][CH2:1][CH2:2][CH2:3][C:4]#[CH:5])([CH3:14])([CH3:13])[CH3:12]

참가 물질

4

반응물 2

HCID 90495Di-tert-butyl dicarbonateHCID 641001Pent-4-yn-1-amine

생성물 1

HCID 22904935tert-butyl N-(pent-4-yn-1-yl)carbamate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of pent-4-ynylamine (480 mg; Li, Y. et al. J. Am. Chem. Soc. 1996, 118, 9295) in DCM (5 mL) was treated with (BOC)2O at rt for 15 min. Evaporation gave the title compound as a colorless oil. 1H NMR (CDCl3) δ 4.68 (s, 1H), 3.24 (q, 2H), 2.25 (td, 2H), 1.97 (t, 1H), 1.70 (quint., 2H), 1.45 (s, 9H).

후처리

  1. customEvaporation

출처 및 근거

ORD 기록
ord-8aa5ab16d34549338222ea65264a6a83
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08093229B2

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