Sodium Hydroxide → Sodium (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

HRID 41822

반응식

HRID 41822 반응식
[CH3:1][C:2]1([CH3:11])[O:6][C@@H:5]([C:7]([O:9]C)=[O:8])[CH2:4][O:3]1.[OH-].[Na+:13]>O1CCOCC1>[CH3:1][C:2]1([CH3:11])[O:6][C@@H:5]([C:7]([O-:9])=[O:8])[CH2:4][O:3]1.[Na+:13]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 853166Methyl (4R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

생성물 1

HCID 23717304Sodium (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Methyl (R)-(+)-2,2-dimethyl-1,3-dioxolane-4-carboxylate (1.00 g, 6.2 mmol) was dissolved in 80% aqueous 1,4-dioxane. 1.2 M aqueous NaOH solution was added (5.2 ml) and the reaction mixture was stirred at room temperature for 3 h. After that the solvents were removed under reduced pressure and a colourless solid was obtained (1.03 g, 6.1 mmol, 98%). The product was used immediately in the next reaction step without further purification.

후처리

  1. customAfter that the solvents were removed under reduced pressure
  2. customa colourless solid was obtained (1.03 g, 6.1 mmol, 98%)
  3. customThe product was used immediately in the next reaction step without further purification

출처 및 근거

ORD 기록
ord-e767e90f8e1a4ff1abfe3845590f2a4a
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08535655B2

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