2,5-Dimethyl-1H-indole → 8-Methyl-(2,5-dimethyl-1H-indol-3-yl)quinoline

HRID 418424

반응식

HRID 418424 반응식
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([CH3:11])=[CH:6][CH:5]=2.[CH3:12][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]2[C:22]=1[N:21]=[CH:20][CH:19]=[C:18]2Cl>CN1CCCC1=O.C(OCC)C>[CH3:12][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]2[C:22]=1[N:21]=[C:20]([C:10]1[C:9]3[C:4](=[CH:5][CH:6]=[C:7]([CH3:11])[CH:8]=3)[NH:3][C:2]=1[CH3:1])[CH:19]=[CH:18]2

참가 물질

5

반응물 2

HCID 709652,5-Dimethyl-1H-indoleHCID 123263354-Chloro-8-methylquinoline

생성물 1

HCID 187294798-Methyl-(2,5-dimethyl-1H-indol-3-yl)quinoline수율 99.7%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 13387N-methyl-2-pyrrolidone용매

반응 조건

온도
140 °C

실험 절차

2,5-Dimethylindole (290 mg) and 8-methyl-4-chloroquinoline (360 mg) were suspended in N-methylpyrolidinone (0.5 ml), and maintained under a nitrogen atmosphere. The reaction was heated to 140° C. with stirring for 45 minutes. On cooling a deep red precipitate formed, the mixture was diluted with diethylether and the solid collected by filtration, and dried to give the sub-title compound (570 mg).

후처리

  1. temperaturemaintained under a nitrogen atmosphere
  2. temperatureOn cooling a deep red precipitate
  3. customformed
  4. filtrationthe solid collected by filtration
  5. customdried

출처 및 근거

ORD 기록
ord-ae91cbb6e53f482bb788d4d9733ac7db
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08093278B2

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