참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 5-Methoxy-2-methylindole | HCID 70642 | — |
| 반응물 | 4-Chloro-8-(trifluoromethyl)quinoline | HCID 90262 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | Quinoline,4-(5-methoxy-2-methyl-1h-indol-3-yl)-8-methyl- | HCID 66651927 | 93.7% |
반응 단계
A mixture of 5-methoxy-2-methylindole (346 mg) and 4-chloro-8-trifluoromethylquinoline (380 mg) in NMP (1 ml) and 4M HCl in dioxane (0.1 ml) was heated at 140° C. for 50 min. Aqueous sodium bicarbonate was added and the mixture was extracted with ethyl acetate. The organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol-acetone as eluent) to give the sub-title compound (465 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08093278B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_01 |
|---|
| ORD ID | ord-1212322d85cc4dc092eb8ba137401bee |
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| 출처 메모 | uspto-grants-2012_01 |
|---|
