Diphenyl Ether → HCID 178516461, 화합물

HRID 418451

반응식

HRID 418451 반응식
[F:1][CH:2]([F:11])[O:3][C:4]1[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=1[NH2:6].[C:12]1([O:18]C2C=CC=CC=2)C=CC=[CH:14][CH:13]=1.CCCC(C)C>C(#N)C>[F:1][CH:2]([F:11])[O:3][C:4]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:5]=1[N:6]=[CH:14][CH:13]=[C:12]2[OH:18]

참가 물질

5

반응물 3

HCID 7583Diphenyl EtherHCID 78922-MethylpentaneHCID 9346202-(Difluoromethoxy)aniline

생성물 1

HCID 178516461HCID 178516461, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

2-difluoromethoxyaniline (7.63 g) and the product from step a) were stirred in acetonitrile (100 ml) overnight. The solvent was removed by evaporation and the solid triturated with 4:1 isohexane/diethyl ether (200 ml) before filtering to give a light green solid. The solid was added portionwise to refluxing diphenylether (120 ml) and continued heating for a further 10 minutes before cooling. The solution was poured into isohexane (600 ml) and the solid filtered off to give the title compound (12.0 g).

후처리

  1. customThe solvent was removed by evaporation
  2. customthe solid triturated with 4:1 isohexane/diethyl ether (200 ml)
  3. filtrationbefore filtering
  4. customto give a light green solid
  5. additionThe solid was added portionwise
  6. temperaturecontinued heating for a further 10 minutes
  7. temperaturebefore cooling
  8. filtrationthe solid filtered off

출처 및 근거

ORD 기록
ord-4cc948c9ffb34d069ef25ec8ec3f8d63
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08093278B2

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