Phosphorus oxychloride → 4-Chloro-8-(difluoromethoxy)quinoline

반응식

[F:1][CH:2]([F:15])[O:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[N:12]=[CH:11][CH:10]=[C:9]2O.P(Cl)(Cl)([Cl:18])=O>>[F:1][CH:2]([F:15])[O:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[N:12]=[CH:11][CH:10]=[C:9]2[Cl:18]

참가 물질

반응물 2

HCID 24813Phosphorus oxychloride

HCID 178516461HCID 178516461, 화합물

생성물 1

HCID 435319324-Chloro-8-(difluoromethoxy)quinoline

실험 절차

The product from step b) was heated to reflux in phosphorus oxychloride (80 ml) for 1 hour. The reagent was evaporated under reduced pressure to give an oil which was carefully poured into a mixture of ice/880 ammonia solution (400 ml) and stirred for 30 minutes. The solid was filtered off and dried in vacuo to give the sub-title compound (6.80 g).

후처리

customThe reagent was evaporated under reduced pressure
customto give an oil which
filtrationThe solid was filtered off
customdried in vacuo

출처 및 근거

ORD 기록: ord-b4394c2c00fa4d369689f08ced98c5be
출처 데이터셋: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08093278B2

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