4-Fluoroaniline → 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid

HRID 418660노트

반응식

HRID 418660 반응식
[C:1]1([NH:7][C:8]([C:10]2([C:13]([OH:15])=[O:14])[CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:16]C1C=CC(N)=CC=1>>[F:16][C:4]1[CH:3]=[CH:2][C:1]([NH:7][C:8]([C:10]2([C:13]([OH:15])=[O:14])[CH2:11][CH2:12]2)=[O:9])=[CH:6][CH:5]=1

참가 물질

3

반응물 2

HCID 97314-FluoroanilineHCID 190968711-(Phenylcarbamoyl)cyclopropanecarboxylic acid

생성물 1

HCID 210815301-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid수율 57%

실험 절차

Following the procedure described above for the compound 161 (scheme 45), but replacing aniline for 4-fluoroaniline, title compound 181 was obtained in 57% yield. MS (m/z): 224.0 (M+H).

출처 및 근거

ORD 기록
ord-27d6eef04c69462a9addcb35f64e745b
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08093264B2

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