7-[1,1-Dimethyl-2-(2-trifluoromethyloxiranyl)ethyl]-2,3-dihydrobenzofuran → 4-(2,3-Dihydro-1-benzofuran-7-yl)-1,1,1-trifluoro-4-methyl-2-{[(1-phenyl-1h-indazol-4-yl)amino]methyl}-2-pentanol

HRID 418795

반응식

HRID 418795 반응식
[CH3:1][C:2]([C:12]1[C:20]2[O:19][CH2:18][CH2:17][C:16]=2[CH:15]=[CH:14][CH:13]=1)([CH3:11])[CH2:3][C:4]1([C:7]([F:10])([F:9])[F:8])[CH2:6][O:5]1.Cl.[C:22]1([N:28]2[C:36]3[CH:35]=[CH:34][CH:33]=[C:32]([NH2:37])[C:31]=3[CH:30]=[N:29]2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[O:19]1[C:20]2[C:12]([C:2]([CH3:1])([CH3:11])[CH2:3][C:4]([CH2:6][NH:37][C:32]3[CH:33]=[CH:34][CH:35]=[C:36]4[C:31]=3[CH:30]=[N:29][N:28]4[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)([OH:5])[C:7]([F:8])([F:9])[F:10])=[CH:13][CH:14]=[CH:15][C:16]=2[CH2:17][CH2:18]1

참가 물질

3

반응물 2

HCID 577755187-[1,1-Dimethyl-2-(2-trifluoromethyloxiranyl)ethyl]-2,3-dihydrobenzofuranHCID 666484521-Phenyl-1H-indazol-4-amine hydrochloride2회

생성물 1

HCID 576159414-(2,3-Dihydro-1-benzofuran-7-yl)-1,1,1-trifluoro-4-methyl-2-{[(1-phenyl-1h-indazol-4-yl)amino]methyl}-2-pentanol

실험 절차

Prepared similarly to Example 7 from racemic 7-{1,1-dimethyl-2-[2-(trifluoromethyl)-2-oxiranyl]ethyl}-2,3-dihydro-1-benzofuran (which may be prepared according to WO 04/063163) and 1-phenyl-1H-indazol-4-amine hydrochloride (as the free base, Intermediate 8).

출처 및 근거

ORD 기록
ord-ebb741a2df6a40c8b44af8efc4c37919
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08093281B2

연결된 노트

불러오는 중…