Pyridine → HCID 87138747, 화합물

HRID 41951

반응식

HRID 41951 반응식
COC1C=C2C(=CC=1OC)C(=O)CCC2.[N:16]1C=CC=CC=1.[N+:22]([C:25]1[CH:47]=[CH:46][C:28]([CH2:29][O:30]/[N:31]=[C:32]2\[CH2:33][CH2:34][CH2:35][C:36]3[C:41]\2=[CH:40][C:39]([O:42][CH3:43])=[C:38]([O:44][CH3:45])[CH:37]=3)=[CH:27][CH:26]=1)([O-])=[O:23].C(OCC)(=O)C.CCCCCC>C(O)C>[N:22]1[O:23][N:16]=[C:47]2[CH:46]=[C:28]([CH2:29][O:30]/[N:31]=[C:32]3\[CH2:33][CH2:34][CH2:35][C:36]4[C:41]\3=[CH:40][C:39]([O:42][CH3:43])=[C:38]([O:44][CH3:45])[CH:37]=4)[CH:27]=[CH:26][C:25]=12

참가 물질

6

반응물 4

HCID 1049PyridineHCID 2668163,4-Dihydro-6,7-dimethoxy-1(2H)-naphthalenoneHCID 21226206Ethyl acetate hexaneHCID 87138450(E)-6,7-dimethoxy-N-[(4-nitrophenyl)methoxy]-3,4-dihydro-2H-naphthalen-1-imine

생성물 1

HCID 87138747HCID 87138747, 화합물수율 88%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

6,7-Dimethoxy-1-tetralone (40 mg, 0.19 mmol) was subjected to reaction with 0-(benzo[c][1,2,5]oxadiazol-5-ylmethyl)hydroxylamine hydrochloride (41 mg, 0.20 mmol) in ethanol (2 mL) and pyridine (0.2 mL, 2.58 mmol) under the same conditions as described for (E)-6,7-dimethoxy-3,4-dihydronaphthalen-1(2H)-one O-4-nitrobenzyl oxime. Subjection of the material obtained on work up to flash chromatography (3:7 v/v ethyl acetate/hexane elution) afforded the title compound as white crystals (60 mg, 88%), m.p. 139-140° C., Rf 0.4.

출처 및 근거

ORD 기록
ord-fc6cca299ab34329b5ce188c59f8f9ed
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536157B2

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