In a microwave vial with septum cap, 5-[3-(2-chloro-4-pyrimidinyl)imidazo[1,2-a]pyridin-2-yl]-N-(2,6-difluorophenyl)-2-(methyloxy)benzamide (Intermediate Example 2) (0.131 g, 0.267 mmol) and 5-ethyl-2-(methyloxy)-4-{4-[2-(methylsulfonyl)ethyl]-1-piperidinyl}aniline (0.091 g, 0.27 mmol) were taken up in 1,1,1-trifluoroethanol (1.5 mL) and 4M HCl in dioxane (0.134 mL, 0.535 mmol) was added. The vial was sealed and heated in the microwave at 180° C. for 40 min. Reaction was complete by MS, it was cooled to rt, neutralized with 7N ammonia in MeOH, and concentrated in vacuo onto silica gel and flash chromatographed. The desired fractions were combined and concentrated and the resulting solid was triturated with diethyl ether, filtered and air dried to give the title compound (0.12 g, 0.15 mmol, 56%). 1H NMR (400 MHz, DMSO-d6) δ ppm 9.75 (s, 1H), 9.23-9.40 (m, 1H), 8.44 (s, 1H), 8.21 (d, J=5.2 Hz, 1H), 8.08 (s, 1H), 7.75 (dd, J=8.4, 1.6 Hz, 1H), 7.67 (d, J=9.0 Hz, 1H), 7.49 (s, 1H), 7.29-7.45 (m, 2H), 7.21-7.29 (m, 1H), 7.07-7.21 (m, 2H), 6.91 (t, J=6.8 Hz, 1H), 6.78 (s, 1H), 6.54 (d, J=5.1 Hz, 1H), 3.95 (s, 3H), 3.76 (s, 3H), 3.06-3.20 (m, 2H), 2.86-3.01 (m, 5H), 2.57-2.72 (m, 2H), 2.51 (q, J=7.5 Hz, 2H), 1.75 (dd, J=11.6, 0.6 Hz, 2H), 1.60-1.71 (m, 2H), 1.40-1.55 (m, 1H), 1.20-1.39 (m, 2H), 1.06 (t, J=7.5 Hz, 3H). MS (M+H, ES+) 796.
