Hydrochloric Acid → 4-(2-Methanesulfonylethyl)piperidine hydrochloride
반응식
[CH3:1][S:2]([CH2:5][CH2:6][CH:7]1[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]1)(=[O:4])=[O:3].[ClH:20]>CO>[ClH:20].[CH3:1][S:2]([CH2:5][CH2:6][CH:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)(=[O:4])=[O:3]참가 물질
4
실험 절차
To 1,1-dimethylethyl 4-[2-(methylsulfonyl)ethyl]-1-piperidinecarboxylate (240 g, 824 mmol) in MeOH at 0° C. was added saturated HCl in MeOH slowly. The suspension was stirred at rt overnight. The mixture was washed with MeOH then dried by vacuum to provide the title compound of Step E (135 g, 593 mmol, 72%). 1H NMR (400 MHz, DMSO-d6) δ 1.25-1.40 (m, 2H), 1.52-1.65 (m, 3H), 1.70-1.80 (m, 2H), 2.68-2.83 (m, 2H), 2.79 (s, 3H), 3.07-3.20 (m, 4H).
후처리
- washThe mixture was washed with MeOH
- customthen dried by vacuum
출처 및 근거
- ORD 기록
- ord-7be7e70763c9459e8c81307989d91836
- 출처 데이터셋
- uspto-grants-2012_01
- 특허 번호
- US08093239B2
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