Sodium Carbonate → HCID 178513428, 화합물

HRID 419692노트

반응식

HRID 419692 반응식
Cl.[NH2:2][OH:3].[C:4]([N:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1)#[N:5].C(=O)([O-])[O-].[Na+].[Na+]>O.CO>[OH:3][NH:2][C:4]([N:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1)=[NH:5]

참가 물질

6

반응물 3

HCID 10340Sodium CarbonateHCID 73736PiperidinocarbonitrileHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 178513428HCID 178513428, 화합물

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

Amidine (e) is readily produced from nitrites. More specifically, hydroxylamine hydrochloride dissolved in a suitable solvent, such as water, is reacted with cyanopiperidine (g) in the presence of a base such as sodium carbonate in a suitable solvent, such as in methanol and exposed to heat to provide the hydroxycarbamimidoyl-piperidine (h). The hydroxycarbamimidoylpiperidine (h) in a suitable solvent, such as acetic acid, is then hydrogenated via palladium catalyst in the presence of acetic acid anhydride under pressure to provide amidine (e).

후처리

  1. temperatureto heat

출처 및 근거

ORD 기록
ord-194efada7bc044ff9ce22b1cd19dc2a6
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08093383B2

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