Potassium Acetate → 5-Phenylpyridin-3-amine

HRID 41986노트

반응식

HRID 41986 반응식
Cl[C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:6][C:5]([N+:14]([O-])=O)=[CH:4][N:3]=1.CC([O-])=O.[K+]>C(O)C.[Pd]>[C:8]1([C:7]2[CH:6]=[C:5]([NH2:14])[CH:4]=[N:3][CH:2]=2)[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

참가 물질

5

반응물 2

HCID 517044Potassium AcetateHCID 463146982-Chloro-5-nitro-3-phenylpyridine

생성물 1

HCID 27629015-Phenylpyridin-3-amine수율 69%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 2-chloro-5-nitro-3-phenylpyridine (0.43 mmol, 0.1 g), KOAc (0.43 mmol, 0.042 g) and Pd/C 10% (0.03 g) in ethanol (4 ml) was stirred for 24 hours under hydrogen atmosphere. The catalyst was filtered off and the solid thoughtfully washed with warm ethanol. The solid residue was purified by chromatography over SiO2 eluting with dichloromethane/methanol mixtures affording 5-phenylpyridin-3-amine (0.05 g, yield 69%) of the expected product.

후처리

  1. filtrationThe catalyst was filtered off
  2. washthe solid thoughtfully washed with warm ethanol
  3. customThe solid residue was purified by chromatography over SiO2 eluting with dichloromethane/methanol

출처 및 근거

ORD 기록
ord-2d7ac8cb0c5048eeba8ab1e599705f42
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536165B2

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