Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 1,1-Dimethylethyl N-[(1-ethynylcyclopropyl)sulfonyl]carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1108658-38-3 | HCID 57816679 | — |
| 반응물 | HCID 178502985 | HCID 178502985 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 1,1-Dimethylethyl N-[(1-ethynylcyclopropyl)sulfonyl]carbamate | HCID 57816689 | 85% |
반응 단계
To a stirred solution of compound 80 (230 mg, 0.92 mmol) in MeOH (5 mL) at 0° C. was added K2CO3 (255 mg, 1.84 mmol), and Ohira-Bestmann reagent (215 g, 1.10 mmol) (Tetr. Lett. 2008, 49, 4454). The mixture was stirred at room temperature for 16 hrs and was concentrated under reduced pressure. Water, EtOAc, and citric acid were added to bring pH to 4-5. Organics were dried over Na2SO4, filtered, and concentrated under reduced pressure to yield compound 81 in 85% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08093379B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-50656435da35495c8fb7a297723df239 |
| 출처 메모 | uspto-grants-2012_01 |