Water → HCID 178487711, 화합물

HRID 420082

반응식

HRID 420082 반응식
Cl[C:2]1[C:11]2[C:6](=[C:7]([Cl:14])[C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[N:5]=[C:4]([N:15]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[N:16]2)[CH:3]=1.CC(O[K])=[O:26].O>CS(C)=O>[Cl:14][C:7]1[C:8]([O:12][CH3:13])=[CH:9][CH:10]=[C:11]2[C:6]=1[N:5]=[C:4]([N:15]1[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[N:16]1)[CH:3]=[C:2]2[OH:26]

참가 물질

5

반응물 3

HCID 962Water2회HCID 56605213HCID 56605213, 화합물HCID 178476685HCID 178476685, 화합물

생성물 1

HCID 178487711HCID 178487711, 화합물수율 80%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
140 °C

실험 절차

To a solution of compound 119b (250 mg) in DMSO (2.5 mL) was added CH3COOK (3 eq.), water (2 eq.). The reaction mixture was heated to 140° C. for 4 hrs. After cooled to RT, water (1 mL) was added to the reaction mixture slowly under stirring. Solid was filtered and washed with water to yield compound 88b in >80% yield. In a separate reaction, when 5 eq. of CH3COOK was used, the reaction was completed in 1 hr.

후처리

  1. temperatureAfter cooled to RT
  2. filtrationSolid was filtered
  3. washwashed with water

출처 및 근거

ORD 기록
ord-dc9bd193c5ad415e9613025dfc85b1ff
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08093379B2

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