참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Fluorophenylboronic acid | HCID 2734354 | — |
| 반응물 | 5-Bromo-2-iodopyrimidine | HCID 7006651 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 5-Bromo-2-(2-fluorophenyl)pyrimidine | HCID 49758695 | 71.4% |
반응 단계
A mixture of 5-bromo-2-iodopyrimidine (2.58 mmol, 0.500 g), 2-fluorophenylboronic acid (3.87 mmol, 0.542 g), 2M aqueous solution of K2CO3 (7.76 mmol, 3.9 ml), Pd(PPh3)4 in dioxane (12 ml) was heated at 110° C. overnight. The solvent was evaporated and the solid residue was extracted between water and ethyl acetate. The organic phase was evaporated and the crude residue was purified by chromatography over SiO2 eluting with hexane/ethyl acetate mixtures affording 0.466 g (yield 56%) of the expected product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08536165B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_09 |
|---|
| ORD ID | ord-db65dc6d4e8a4422803c0cb854df8532 |
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| 출처 메모 | uspto-grants-2013_09 |
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