反应详情

温度

110 °C

A mixture of 5-bromo-2-iodopyrimidine (2.58 mmol, 0.500 g), 2-fluorophenylboronic acid (3.87 mmol, 0.542 g), 2M aqueous solution of K2CO3 (7.76 mmol, 3.9 ml), Pd(PPh3)4 in dioxane (12 ml) was heated at 110° C. overnight. The solvent was evaporated and the solid residue was extracted between water and ethyl acetate. The organic phase was evaporated and the crude residue was purified by chromatography over SiO2 eluting with hexane/ethyl acetate mixtures affording 0.466 g (yield 56%) of the expected product.

1. customThe solvent was evaporated
2. extractionthe solid residue was extracted between water and ethyl acetate
3. customThe organic phase was evaporated
4. customthe crude residue was purified by chromatography over SiO2 eluting with hexane/ethyl acetate