참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Amino-5-fluorobenzoic acid | HCID 101412 | — |
| 반응물 | Hydrochloride methanol | HCID 21893726 | — |
| 생성물 | Methyl 2-amino-5-fluorobenzoate | HCID 2783401 | 42% |
반응 단계
A solution of 2-amino-5-fluorobenzoic acid (9.29 mmol, 1.440 g) in a mixture of HCl/MeOH (3N, 30 ml) was heated at 100° C. overnight. The solvent was evaporated and the crude mixture was extracted between DCM and K2CO3 saturated aqueous solution. The organic phase was evaporated and the crude mixture was purified by chromatography over SiO2 with hexane/ethyl acetate mixtures affording 0.650 g (yield 42%) of the expected product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08536165B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_09 |
|---|
| ORD ID | ord-40ac5aa251c046e8afc1ac46c6d942ed |
|---|
| 출처 메모 | uspto-grants-2013_09 |
|---|
