Anthranilic Acid → Ethyl 2-aminobenzoate

HRID 42036

반응식

HRID 42036 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].OS(O)(=O)=O.[CH2:16](O)[CH3:17]>>[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH2:16][CH3:17])=[O:5]

참가 물질

4

반응물 3

HCID 227Anthranilic AcidHCID 702EthanolHCID 1118Sulfuric Acid

생성물 1

HCID 6877Ethyl 2-aminobenzoate수율 78%

실험 절차

To a solution of 2-aminobenzoic acid (7.29 mmol, 1.0 g) in ethanol (20 ml), H2SO4 (45 mmol, 2.5 ml) was added and the mixture was refluxed for 20 hours. The solvent was evaporated and the crude residue was dissolved in water. The solution neutralised with 6N NaOH aqueous solution and extracted with CHCl3. The organic phase was evaporated affording 0.939 g (yield 78%) of the expected product.

후처리

  1. temperaturethe mixture was refluxed for 20 hours
  2. customThe solvent was evaporated
  3. dissolutionthe crude residue was dissolved in water
  4. extractionextracted with CHCl3
  5. customThe organic phase was evaporated

출처 및 근거

ORD 기록
ord-4b37735ad9534962a4502eed81159ae0
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536165B2

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