Hydrochloric Acid → Tetrahydro-pyran-4-carboxylic acid [7-aminomethyl-6-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-amide

HRID 420535노트

반응식

HRID 420535 반응식
C(OC(=O)[NH:7][CH2:8][C:9]1[C:14]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=2[Cl:22])=[CH:13][N:12]2[C:23]([NH:26][C:27]([CH:29]3[CH2:34][CH2:33][O:32][CH2:31][CH2:30]3)=[O:28])=[CH:24][N:25]=[C:11]2[CH:10]=1)(C)(C)C.Cl>O1CCOCC1>[NH2:7][CH2:8][C:9]1[C:14]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=2[Cl:22])=[CH:13][N:12]2[C:23]([NH:26][C:27]([CH:29]3[CH2:30][CH2:31][O:32][CH2:33][CH2:34]3)=[O:28])=[CH:24][N:25]=[C:11]2[CH:10]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 57906481{6-(2,4-Dichloro-phenyl)-3-[(tetrahydro-pyran-4-carbonyl)-amino]-imidazo[1,2-a]pyridin-7-ylmethyl}-carbamic acid tert-butyl ester

생성물 1

HCID 57906482Tetrahydro-pyran-4-carboxylic acid [7-aminomethyl-6-(2,4-dichloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-amide수율 77.1%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

To a solution of {6-(2,4-dichloro-phenyl)-3-[(tetrahydro-pyran-4-carbonyl)-amino]-imidazo[1,2-a]pyridin-7-ylmethyl}-carbamic acid tert-butyl ester (79.5 mg, 0.153 mmol) in dioxane (3 mL) was added a 4M HCl solution in dioxane (2 mL) and the mixture was stirred at RT for 15 min. The formed precipitate was filtered and dried under vacuum to yield the title compound (2HCl salt, 58 mg, 0.118 mmol, 48%) as a brownish solid. MS: 419 [M+1]+; HPLC: AtRet=0.83.

후처리

  1. filtrationThe formed precipitate was filtered
  2. customdried under vacuum

출처 및 근거

ORD 기록
ord-24070c377f5b4c25bbe34459ed13d069
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08097617B2

반응 노트

불러오는 중…