Methanol → Methyl 2-chloro-4-methylbenzoate

HRID 420753

반응식

HRID 420753 반응식
[Cl:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].O=S(Cl)Cl.[CH3:16]O>>[Cl:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH3:16])=[O:5]

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 27357552-Chloro-4-methylbenzoic acid

생성물 1

HCID 22019481Methyl 2-chloro-4-methylbenzoate

실험 절차

2-chloro-4-methylbenzoic acid (500 mg, 2.93 mmol) was dissolved in Methanol (7 mL) and SOCl2 (0.215 mL, 2.93 mmol) was slowly added to the mixture and the reaction was left at room temperature overnight. Next morning HPLC showed completion. Volatiles were removed under vacuum to afford 526 mg of the title compound as brown oil.

후처리

  1. customVolatiles were removed under vacuum

출처 및 근거

ORD 기록
ord-816d5ce1e99a4848bd036311ac824933
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08097628B2

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