Chloroform → 1-Cycloheptylpropan-2-one

HRID 420882

반응식

HRID 420882 반응식
[C:1]1(=O)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.ClC1C=CC=[C:12]([C:16]([O:18]O)=O)C=1.[CH:20](Cl)(Cl)Cl>>[CH:1]1([CH2:20][C:16](=[O:18])[CH3:12])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 3

HCID 6212Chloroform2회HCID 10400CycloheptanoneHCID 70297m-Chloroperbenzoic acid

생성물 1

HCID 2274131-Cycloheptylpropan-2-one

실험 절차

A solution of cycloheptanone (5 gms, 44 mmol) in chloroform (100 ml) was added to a solution of m-chloroperbenzoic acid (12.3 gms, 79.3 mmol) in chloroform (75 ml) and stirred at rt for 36 hrs. The reaction mixture was filtered and the filtrate washed with aq Na2CO3 solution (5%, 3×50 ml) until pH aq layer was at 8-9. Organic layer was washed with water and brine and dried over Na2SO4. The insolubles wer filtered off and the organic layer was concentrated under vacuum to give the lactone (20) (3.5 gms) as waxy solid.

후처리

  1. filtrationThe reaction mixture was filtered
  2. washthe filtrate washed with aq Na2CO3 solution (5%, 3×50 ml) until pH aq layer
  3. washOrganic layer was washed with water and brine
  4. dry with materialdried over Na2SO4
  5. filtrationThe insolubles wer filtered off
  6. concentrationthe organic layer was concentrated under vacuum

출처 및 근거

ORD 기록
ord-55c994096a2748869f9c4498d559ad60
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08097728B2

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