Ammonium formate → (Octahydropyrrolo[1,2-a]pyrazin-8a-yl)methanol
반응식
C1(C[N:8]2[CH2:13][CH2:12][N:11]3[CH2:14][CH2:15][CH2:16][C:10]3([CH2:17][OH:18])[CH2:9]2)C=CC=CC=1.C([O-])=O.[NH4+]>CO.[Pd]>[CH2:9]1[NH:8][CH2:13][CH2:12][N:11]2[CH2:14][CH2:15][CH2:16][C:10]12[CH2:17][OH:18]참가 물질
5
실험 절차
To a solution of [2-(phenylmethyl)hexahydropyrrolo[1,2-a]pyrazin-8a(6H)-yl]methanol (D66, 180 mg) in anhydrous methanol (5 mL) under a Nitrogen atmosphere at rt, ammonium formate (475 mg) and palladium (10% on carbon, 13 mg) were added. The resulting suspension was heated at reflux temperature for 3.5 hours, then allowed to cool to r.t. and filtered over Celite. The organic extract was dried and concentrated in vacuo to give the desired compound (120 mg) as orange waxy solid.
후처리
- temperatureThe resulting suspension was heated
- temperatureat reflux temperature for 3.5 hours
- filtrationfiltered over Celite
- extractionThe organic extract
- customwas dried
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-e79ee58d489b4fad9709b3b7fcd306ce
- 출처 데이터셋
- uspto-grants-2012_01
- 특허 번호
- US08097618B2
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