1-(2-Hydroxyethyl)piperazine → 6-(4-(2-Hydroxyethyl)piperazin-1-yl)-nicotinamide

HRID 421714노트

반응식

HRID 421714 반응식
Cl[C:2]1[CH:27]=[CH:26][C:5]([C:6]([NH:8]C2C=CC(Cl)=C(NC(=O)C3C=CC=C(Cl)C=3)C=2)=[O:7])=[CH:4][N:3]=1.[N:28]1([CH2:34][CH2:35][OH:36])[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[OH:36][CH2:35][CH2:34][N:28]1[CH2:33][CH2:32][N:31]([C:2]2[CH:27]=[CH:26][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][N:3]=2)[CH2:30][CH2:29]1

참가 물질

3

반응물 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 167312706-chloro-N-(4-chloro-3-(3-chlorobenzamido)phenyl)nicotinamide

생성물 1

HCID 123642326-(4-(2-Hydroxyethyl)piperazin-1-yl)-nicotinamide

실험 절차

6-chloro-N-(4-chloro-3-(3-chlorobenzamido)phenyl)nicotinamide (0.143 mmol) was used in general procedure 3 with 2-(piperazin-1-yl)ethanol (0.71 mmol). The product was purified by RP-HPLC to give N-(4-chloro-3-(3-chlorobenzamido)phenyl))-6-(4-(2-hydroxyethyl)piperazin-1-yl)-nicotinamide. MS (Q1) 498.0 (M)+

후처리

  1. customThe product was purified by RP-HPLC

출처 및 근거

ORD 기록
ord-24c334eef30540efa3f3281b117e5986
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101610B2

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