Potassium Hydroxide → 4-(1-Oxo-indan-5-yloxy)-benzamide

HRID 422217노트

반응식

HRID 422217 반응식
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:11][C:12]3[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=3)=[CH:8][CH:9]=2)[CH2:4][CH2:3]1.[OH-:20].[K+]>C(O)(C)(C)C>[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:11][C:12]3[CH:19]=[CH:18][C:15]([C:16]([NH2:17])=[O:20])=[CH:14][CH:13]=3)=[CH:8][CH:9]=2)[CH2:4][CH2:3]1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 597506434-(1-Oxo-indan-5-yloxy)-benzonitrile

생성물 1

HCID 597506634-(1-Oxo-indan-5-yloxy)-benzamide수율 5.8%

시약·촉매·용매 1

HCID 6386tert-Butanol용매

실험 절차

Combine 4-(1-Oxo-indan-5-yloxy)-benzonitrile (1.64 g, 6.58 mmol), tert-butyl alcohol (50 ml), and grounded KOH (1.85 g, 32.89 mmol) at room temperature under nitrogen atmosphere. Stir the reaction for 24 hours then concentrate under reduced pressure. Add Ethyl acetate to the reaction mixture and wash with brine. Dry the organic layer over Na2SO4. A yellow-mange solid precipitates out to afford 101.0 mg, 0.38 mmol (5.7% yield) of the title compound: No Characterization—Characterized by sequential reaction.

후처리

  1. customat room temperature
  2. customthe reaction for 24 hours
  3. concentrationthen concentrate under reduced pressure
  4. washAdd Ethyl acetate to the reaction mixture and wash with brine
  5. dry with materialDry the organic layer over Na2SO4
  6. customA yellow-mange solid precipitates out

출처 및 근거

ORD 기록
ord-6f3198d2da994130a586221560d03f30
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101638B2

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