4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline → 4-Methyl-3-(1-(1,1,1-trifluoropropan-2-yloxy)phthalazin-6-yl)benzenamine

HRID 422570

반응식

HRID 422570 반응식
Cl[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([O:12][CH:13]([CH3:18])[C:14]([F:17])([F:16])[F:15])=[N:7][N:6]=[CH:5]2.[CH3:19][C:20]1[CH:25]=[CH:24][C:23]([NH2:26])=[CH:22][C:21]=1B1OC(C)(C)C(C)(C)O1>>[CH3:19][C:20]1[CH:25]=[CH:24][C:23]([NH2:26])=[CH:22][C:21]=1[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([O:12][CH:13]([CH3:18])[C:14]([F:17])([F:16])[F:15])=[N:7][N:6]=[CH:5]2

참가 물질

3

반응물 2

HCID 160860894-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)anilineHCID 66675982Phthalazine, 6-chloro-1-(2,2,2-trifluoro-1-methylethoxy)-

생성물 1

HCID 666757394-Methyl-3-(1-(1,1,1-trifluoropropan-2-yloxy)phthalazin-6-yl)benzenamine

실험 절차

The title compound was prepared according to a procedure similar to that described in Example 225, using 6-chloro-1-(1,1,1-trifluoropropan-2-yloxy)phthalazine and 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine as starting materials. MS (ESI, pos. ion) m/z: 348.1 (M+1). The racemic material was subjected to Preparative SFC separation using a chiral column to afford its (R)- and (S)-enantiomers.

후처리

  1. customThe racemic material was subjected to Preparative SFC separation

출처 및 근거

ORD 기록
ord-e31646723b8647f9bac97b0a8f9b1c35
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101612B2

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