Hydrochloric Acid → Ethyl 2-(2-methoxyphenyl)acetimidate

HRID 42264노트

반응식

HRID 42264 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]#[N:11].Cl.[CH2:13]([OH:15])[CH3:14]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10](=[NH:11])[O:15][CH2:13][CH3:14]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 81496(2-Methoxyphenyl)acetonitrile

생성물 1

HCID 23025455Ethyl 2-(2-methoxyphenyl)acetimidate

실험 절차

Into a 500 mL round-bottomed flask was added 2-(2-methoxyphenyl)acetonitrile (50.45 g, 343 mmol) in ethanol (101 mL). HCl (10.42 mL, 343 mmol) gas was bubbled through the suspension for 15 minutes. The HCl bubbler was removed and the reaction was stirred at ambient temperature for 48 hours. The reaction was diluted with 200 mL ether, and the suspension was filtered. The collected solid was washed with ether and dried under vacuum to provide the title compound as the hydrochloride salt. MS (DCI+) m/e 194.0 (M+H)+.

후처리

  1. customThe HCl bubbler was removed
  2. additionThe reaction was diluted with 200 mL ether
  3. filtrationthe suspension was filtered
  4. washThe collected solid was washed with ether
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-60df3e3b2ff341b187111c1f4d18894b
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536180B2

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