4-Chlorophenyl cyclopropyl ketone → (4-chlorophenyl)(cyclopropyl)methanone O-methyl oxime

HRID 423023

반응식

HRID 423023 반응식
Cl.[O:2]([NH2:4])[CH3:3].[Cl:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([CH:14]2[CH2:16][CH2:15]2)=O)=[CH:8][CH:7]=1>N1C=CC=CC=1>[CH3:3][O:2][N:4]=[C:12]([C:9]1[CH:8]=[CH:7][C:6]([Cl:5])=[CH:11][CH:10]=1)[CH:14]1[CH2:16][CH2:15]1

참가 물질

4

반응물 2

HCID 811484-Chlorophenyl cyclopropyl ketoneHCID 521874O-Methylhydroxylamine hydrochloride

생성물 1

HCID 73696106(4-chlorophenyl)(cyclopropyl)methanone O-methyl oxime수율 87.4%

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
25 °C

실험 절차

Methoxylamine hydrochloride (2.004 g) was added to (4-chlorophenyl)(cyclopropyl)methanone (2.71 g) in pyridine (60 mL) at 25° C. The resulting solution was stirred at 25° C. for 24 hours. The pyridine was removed in vacuo, and the residual solid extracted with ether. Filtration and evaporation of the solvent gave the crude (4-chlorophenyl)(cyclopropyl)methanone O-methyl oxime (2.75 g, 87%) as a yellow oil. This material was used directly in the next step without further purification.

후처리

  1. customThe pyridine was removed in vacuo
  2. extractionthe residual solid extracted with ether
  3. filtrationFiltration and evaporation of the solvent

출처 및 근거

ORD 기록
ord-820c7f43ceda4a6a8685cd0aafeb45e2
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101623B2

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