Hydrochloric Acid → methyl (3R)-3-amino-3-(4-chlorophenyl)propanoate

HRID 423059노트

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HRID 423059 반응식
Cl.C(OC([NH:9][C@@H:10]([C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=1)[CH2:11][C:12]([O:14][CH3:15])=[O:13])=O)(C)(C)C>C(Cl)Cl>[NH2:9][C@@H:10]([C:16]1[CH:17]=[CH:18][C:19]([Cl:22])=[CH:20][CH:21]=1)[CH2:11][C:12]([O:14][CH3:15])=[O:13]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 57750353HCID 57750353, 화합물2회

생성물 1

HCID 2400965methyl (3R)-3-amino-3-(4-chlorophenyl)propanoate수율 115.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

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온도
20 °C

실험 절차

Hydrochloric acid (4.0M in dioxane) (7.89 mL, 31.55 mmol) was added in one portion to (R)-methyl 3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propanoate (Intermediate 39) (990 mg, 3.16 mmol) in DCM (20 mL) at 20° C. The resulting solution was stirred at 20° C. for 3 hours. The reaction mixture was evaporated to afford (R)-methyl 3-amino-3-(4-chlorophenyl)propanoate (hydrochloride) (777 mg, 98%) as a yellow solid.

후처리

  1. customThe reaction mixture was evaporated

출처 및 근거

ORD 기록
ord-36d53d0f380948e3a841cb5ab579dc02
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101623B2

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