2-Butyn-1-ol → 4-(2-Butynyloxy)-5,6-difluoropyrimidine
반응식
[F:1][C:2]1[C:7]([F:8])=[C:6](F)[N:5]=[CH:4][N:3]=1.[CH2:10]([OH:14])[C:11]#[C:12][CH3:13].C(N(CC)C(C)C)(C)C>O1CCCC1>[CH2:10]([O:14][C:6]1[C:7]([F:8])=[C:2]([F:1])[N:3]=[CH:4][N:5]=1)[C:11]#[C:12][CH3:13]참가 물질
5
실험 절차
0.5 g of 4,5,6-trifluoropyrimidine, 0.31 g of 2-butyn-1-ol and 0.62 ml of N,N-diisopropylethylamine were added to 1 ml of tetrahydrofuran, then the mixture was stirred at room temperature for 1 hour. Then the reaction mixture was subjected to silica gel column chromatography to obtain 0.52 g of 4-(2-butynyloxy)-5,6-difluoropyrimidine.
출처 및 근거
- ORD 기록
- ord-9cb7ae22c3f94ae0b9d0b93c8cb2393f
- 출처 데이터셋
- uspto-grants-2012_01
- 특허 번호
- US08101753B2
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