3-(Trifluoromethyl)piperidine → 4-(2-Butynyloxy)-6-(3-trifluoromethylpiperidino)pyrimidine

HRID 423165

반응식

HRID 423165 반응식
[CH2:1]([O:5][C:6]1[CH:11]=[C:10](F)[N:9]=[CH:8][N:7]=1)[C:2]#[C:3][CH3:4].[F:13][C:14]([F:22])([F:21])[CH:15]1[CH2:20][CH2:19][CH2:18][NH:17][CH2:16]1>C1(C)C=CC=CC=1>[CH2:1]([O:5][C:6]1[CH:11]=[C:10]([N:17]2[CH2:18][CH2:19][CH2:20][CH:15]([C:14]([F:22])([F:21])[F:13])[CH2:16]2)[N:9]=[CH:8][N:7]=1)[C:2]#[C:3][CH3:4]

참가 물질

4

반응물 2

HCID 27607763-(Trifluoromethyl)piperidineHCID 596619694-(2-Butynyloxy)-6-fluoropyrimidine

생성물 1

HCID 576729514-(2-Butynyloxy)-6-(3-trifluoromethylpiperidino)pyrimidine

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

0.2 g of 4-(2-butynyloxy)-6-fluoropyrimidine and 0.15 g of 3-trifluoromethylpiperidine are added to 1 ml of toluene, then the mixture is stirred at room temperature for 30 minutes. Then the reaction mixture is subjected to silica gel column chromatography to obtain 4-(2-butynyloxy)-6-(3-trifluoromethylpyperidino)pyrimidine (referred as the present compound (10) hereinafter).

출처 및 근거

ORD 기록
ord-396961e1920d455cb9aea8f8df2fdd63
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101753B2

연결된 노트

불러오는 중…