Cyanide → 3-Bromopyridine-2-carbonitrile

HRID 423177노트

반응식

HRID 423177 반응식
[Br:1][C:2]1[CH:3]=[N+:4]([O-])[CH:5]=[CH:6][CH:7]=1.[C-:9]#[N:10]>N1C=CC=CC=1>[Br:1][C:2]1[C:3]([C:9]#[N:10])=[N:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 5975CyanideHCID 142763Pyridine, 3-bromo-, 1-oxide

생성물 1

HCID 8176943-Bromopyridine-2-carbonitrile

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

In Scheme I is described the preparation of pyridine intermediates (5) and (6). In Scheme I, Step 1,3-bromopyridine (1) is oxidized to 3-bromo-pyridine-N-oxide (2). In Scheme I, Step 2, cyanide addition gives 3-bromo-pyridine-2-carbonitrile (3). The nitrile of formula (3) is hydrolyzed to the carboxylic acid and esterified with acid catalysis to the ester of formula (4). In Scheme I, Step 4, the ester is reduced to the pyridylmethanol of formula (5a) using sodium borohydride.

출처 및 근거

ORD 기록
ord-0d6d80b5e8f347ff8cbffc974dbc79d0
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101761B2

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