Sodium Hydroxide → 5-[4-(benzyloxy)phenyl]-2H-tetrazole

HRID 423254

반응식

HRID 423254 반응식
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N-:17]=[N+:18]=[N-:19].[Na+].[Cl-].[NH4+].[OH-].[Na+]>CN(C)C=O>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]2[N:17]=[N:18][NH:19][N:14]=2)=[CH:15][CH:16]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

6

반응물 4

HCID 14798Sodium HydroxideHCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 5613714-Benzyloxybenzonitrile

생성물 1

HCID 47709095-[4-(benzyloxy)phenyl]-2H-tetrazole수율 95%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
110 °C

실험 절차

To a solution of 4-benzyloxybenzonitrile (2.0 g) in dimethylformamide (15 mL) were added sodium azide (932 mg) and ammonium chloride (767 mg). The mixture was stirred at 110° C. overnight under heating and then allowed to stand for cooling to room temperature. 1N aqueous sodium hydroxide was added thereto to adjust the pH to about 10, followed by washing with diethyl ether. To the aqueous layer was added 1N hydrochloric acid, and the resulting precipitated solid was filtered to give the title compound (2.29 g).

후처리

  1. temperatureunder heating
  2. temperaturefor cooling to room temperature
  3. washby washing with diethyl ether
  4. additionTo the aqueous layer was added 1N hydrochloric acid
  5. customthe resulting precipitated solid
  6. filtrationwas filtered

출처 및 근거

ORD 기록
ord-aa7d65929a8b4b7f87d2782eda47a500
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101774B2

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